LG 26 LU Note that the ordering of mutation categories in this file is not the same as ours. In aggregating samples by cancer types, for some cancer types, pertinent information may be muddled up as there may be biologic factors one may wish to understand, e. A goal of early detection via blood tests is behind Grail, Inc. Lin D. What this means is that the signature is close to the properly normalized underlying occurrence counts data either aggregated or appropriately averaged over all samplesand NMF samplings fail to find a local minimum substantially different along this particular direction from the local minima that include this cancer signature. LG 42LC4. A4E6, L9.
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The genomic landscape of hypodiploid acute lymphoblastic leukemia. This article has been cited by other articles in PMC. Furthermore, NMF does not fix the number of signatures Kwhich must be either guessed or obtained via trial and error, thereby further adding to the computational cost. Papaemmanuil E. We address breast cancer in Section 4 hereof.
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Mutation Clusters from Cancer Exome
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